Locke & Key: Alpha #2 is the second issue of the Alpha series, and the thirty-seventh issue overall, as well as the final issue of the comic series.
"The End." A door claps softly shut. A key scrapes in a last rusted lock. It ends here: the story of the Locke children and their desperate, tragic battle with the monster set on destroying them... the past. Join Gabriel Rodriguez and Joe Hill for the final chapter of Locke & Key.
- The issue was originally expected to be released on October 30, 2013, before being shifted to November 27, 2013, and later confirmed to be released on December 18.
- The F-Variant cover by Dave Sim is an homage to Amazing Spiderman #29.
- In symbolic end to the initial series, the last panel of the issue, with the Death's Head Moth flying over a door, mirrors the first panel from Locke & Key: Welcome to Lovecraft #1. Only, instead of the door of the Locke's former home in Mendocino Valley, it was the door of the Wellhouse.